Rabbit Liver S9

Details

Rabbit liver S9 fraction is a subcellular fraction containing both cytosolic and microsomal enzyme systems. It is widely used in drug metabolism studies, toxicological evaluation, and metabolite identification due to its complete phase I and phase II metabolic enzyme activities, providing comprehensive support for in vitro metabolism research. Because liver S9 retains full metabolic enzyme activity and is prepared through standardized procedures, it serves as an important tool for early drug screening and metabolism studies. At MileCell, the liver S9 fraction is prepared via ultracentrifugation, followed by characterization of CYP450 enzyme activity and protein concentration. We offer standardized S9 products derived from various species to meet diverse research needs.

Product Features

• Quality assurance: All batches undergo comprehensive quality control procedures to ensure product integrity and batch-to-batch consistency.
• Comprehensive characterization: Characterization of key CYP450 and phase II enzyme activities, ensuring exceptional metabolic performance and specificity for consistent and reliable results.
• Scalable production: Large lots derived from donor pools of liver subcellular fractions to minimize lot-to-lot variation and ensure long-term availability across experimental replicates.
• Well-stocked, fresh & viable inventory‌.
• Customizable: Gender, species, vial size, batch size, etc.

Quality

• Protein concentration: 20 mg/mL
• Metabolic activity: Characterization of phase I (CYP1A, CYP2B, CYP3A) and phase II (UGT) drug metabolizing enzymes
• Metabolic stability: Determine the half-life of Testosterone, Verapamil, Raloxifene