Rabbit Intestine S9

Details

Rabbit intestine S9 is a subcellular fraction containing the complete metabolic enzyme system of the intestine, offering unique advantages in intestine metabolism and toxicity studies. Its comprehensive phase I and phase II metabolic enzyme systems enable a thorough evaluation of the metabolic transformation of drugs in the intestine. As intestine S9 can simultaneously reflect intestine metabolism and detoxification functions, it has become an important model for the safety evaluation of oral drugs. Isolated via differential centrifugation and validated for enzyme activity by MileCell, these S9 fractions are available from multiple species including mouse, rat, dog, monkey, minipig, rabbit, feline, hamster, etc.

Product Features

• Quality assurance: All batches undergo comprehensive quality control procedures to ensure product integrity and batch-to-batch consistency.
• Comprehensive characterization: Characterization of key CYP450 and Phase II enzyme activities, ensuring exceptional metabolic performance and specificity for consistent and reliable results.
• Scalable production: Large lots derived from donor pools of intestine subcellular fractions to minimize lot-to-lot variation and ensure long-term availability across experimental replicates.
• Available intestine preparations format: PMSF-containing‌ and PMSF-free.
• Well-stocked, fresh & viable inventory‌.
• Customizable: Gender, species, vial size, batch size, etc.

Quality

• Protein concentration: 10 mg/mL
• Metabolic activity
• Metabolic stability: Determine the half-life of Testosterone, Verapamil, Raloxifen