With EUROTOX 2026 just weeks away, MileCell Biotechnology is looking forward to joining the international toxicology community in Vienna from September 13–16, 2026. This year marks EUROTOX’s 60th Congress Anniversary, held under the theme “Toxicology without borders.”

Toxicology increasingly asks more than whether a safety signal is present. Researchers also need to understand what drives that signal—metabolic activation, tissue-specific response, inflammatory signaling, or prolonged cellular stress—and whether an in vitro system reflects the biology relevant to the question. At Booth #7, MileCell will highlight biological models and workflow tools designed to support these decisions across genotoxicity, hepatotoxicity, drug metabolism, and mechanistic safety research.

A Toxicology-Focused Portfolio for Different Stages of Safety Research

A compound’s safety profile can depend heavily on how it is metabolized and which cell types are involved in the response. For EUROTOX 2026, our focus is on practical in vitro systems that help researchers connect metabolism with toxicological outcomes—from metabolic activation assays to liver-focused cellular models and supporting reagents.

Induced Liver S9 for Genotoxicity and Metabolic Activation

For genotoxicity workflows that require an exogenous metabolic activation system, MileCell offers Induced Liver S9 from Sprague Dawley rat and LVG hamster. Co-induction with sodium phenobarbital (PB) and β-naphthoflavone (NF) supports broad expression of key Phase I drug-metabolizing enzymes, with CYP1A, CYP2B, and CYP3A activities systematically characterized.

The products are designed for applications including the Ames test, in vitro chromosome aberration assay, micronucleus testing, environmental toxicology screening, and drug safety evaluation. MileCell Induced Liver S9 has also been functionally evaluated in Ames and chromosome aberration assay systems, providing a ready-to-use option for studies where reliable metabolic activation is essential.

Primary Hepatocytes for Metabolism-Aware Hepatotoxicity Research

Primary hepatocytes remain a central model for studying hepatic metabolism and toxicity. MileCell provides both suspension and plateable hepatocytes across multiple species, with post-thaw functional characterization designed to support consistent in vitro performance.

Plateable hepatocytes can be used in monolayer, sandwich culture, and spheroid formats, supporting hepatotoxicity assessment, prolonged hepatic metabolism, transporter studies, and investigation of chronic drug-induced liver injury mechanisms. Format selection can be matched to the biological question and study duration.

Liver Non-Parenchymal Cells for Inflammation and Fibrosis Biology

Toxic liver responses are not driven by hepatocytes alone. Kupffer cells, hepatic stellate cells, and liver sinusoidal endothelial cells contribute to inflammatory signaling, fibrotic processes, tissue repair, microcirculation, and immune-cell trafficking. MileCell’s liver NPC portfolio includes these individual cell types as well as NPC Mix products for co-culture applications.

For mechanistic toxicology studies, these models provide additional cellular context for exploring how liver injury develops beyond direct hepatocyte effects. MileCell NPCs are functionally characterized and can support both 2D culture and 3D co-culture workflows.

Subcellular Fractions for Metabolism, Bioactivation, and Mechanistic Studies

When a cell-free system is more appropriate, MileCell provides a broad portfolio of subcellular fractions, including microsomes, S9 fractions, cytosol, lysosomes, and tissue homogenates. Preparations are available from liver, intestine, kidney, lung, and skin tissues across multiple species.

These systems support metabolic stability, intrinsic clearance, enzyme phenotyping, CYP and UGT inhibition, metabolite characterization, and related drug metabolism studies. Intestinal subcellular fractions can also help investigate first-pass biotransformation, including processes that contribute to bioactivation or detoxification of xenobiotics.

Supporting Reproducible Primary-Cell Workflows

Reliable cellular models also depend on consistent handling and culture conditions. MileCell provides cell type-specific thawing, plating, culture, and maintenance media, together with Collagen I coated culture plates. These workflow tools are designed to support primary-cell attachment, viability, function, and reproducibility across routine and higher-throughput assay formats.

What Can We Discuss at Booth #7?

If you are attending EUROTOX 2026, stop by Booth #7 to talk with the MileCell team about fit-for-purpose model selection for your safety program. Topics we would be glad to discuss include:

• Selecting an appropriate metabolic activation system for genotoxicity assays

• Choosing between suspension, plateable, sandwich-culture, or spheroid hepatocyte workflows

• Adding Kupffer cells, stellate cells, LSECs, or NPC Mix to liver-focused mechanistic studies

• Matching species, tissue source, and subcellular preparation to metabolism and toxicology questions

• Improving consistency in primary-cell culture with optimized media and Collagen I coated plates

Whether your work centers on genotoxicity, metabolic activation, hepatotoxicity, liver injury mechanisms, or broader preclinical safety questions, we look forward to learning more about your research and discussing where a biologically relevant in vitro system may fit into your workflow.

EUROTOX 2026 | September 13–16, 2026 | Vienna, Austria | Booth #7

Contact: Info@milecell-bio.com