Induced LVG Hamster Liver S9

Details

Induced liver S9 from Sprague-Dawley (SD) rat or LVG hamster provide reliable and high-activity metabolic activation systems for in vitro genotoxicity testing. Co-induction with sodium phenobarbital (PB) and β-naphthoflavone (NF) ensures broad expression of key phase I drug-metabolizing enzymes, making the product well-suited for applications such as the Ames test, chromosome aberration assay, and other in vitro genotoxicity studies, offering a dependable tool for drug safety assessment and environmental toxicology research.

Product Features

• Ready-to-use convenience: Carefully formulated to preserve enzymatic integrity and functional activity for immediate use, eliminating complex preparation steps and enabling convenient handling.
• Rigorous quality control: Each batch undergoes stringent quality control to guarantee excellent batch-to-batch reproducibility, including sterility testing, metabolic activity profiling, etc.
• Broad CYP enzyme coverage: Enzyme activities of CYP1A, CYP2B, and CYP3A are systematically characterized, supporting metabolic activation of a wide range of indirect-acting mutagens and pro-carcinogens.
• Functionally validated in multiple assay systems: MileCell induced Liver S9 demonstrates robust metabolic activation across multiple assay systems. In the Ames test, clear dose-dependent increases in revertant colonies were observed with indirect-acting mutagens such as 2-aminoanthracene. In the chromosome aberration assay, cyclophosphamide (CP) treatment in the presence of Induced Liver S9 resulted in statistically significant structural aberrations in CHL cells, confirming strong metabolic activation capacity.

Quality

• Protein concentration: 30 mg/mL
• Metabolic activity: Well-characterized activities of drug-metabolizing enzymes including CYP1A, CYP2B and CYP3A isoforms
• Genetic toxicity qualification: Compliant with AMES test and chromosomal aberration assay requirements
• Microbial testing: Negative