Dog Liver Microsomes

Details

Dog liver microsomes are subcellular fractions enriched with intact drug-metabolizing enzymes, including cytochrome P450 (CYP) enzymes, UDP-glucuronosyltransferases (UGTs), and flavin-containing monooxygenases (FMOs). They are essential in vitro tools for studying metabolic stability, drug–drug interactions, toxic metabolite formation, and interspecies differences. MileCell provides high-quality liver microsomes from multiple species, including mouse, rat, dog, monkey, minipig, rabbit, feline, hamster, etc.

Product Features

• Quality assurance: All batches undergo comprehensive quality control procedures to ensure product integrity and batch-to-batch consistency.
• Comprehensive characterization: Key CYP and phase II enzyme activities are characterized to ensure consistent metabolic performance and specificity.
• Scalable production: Large lots derived from pooled liver subcellular fractions minimize lot-to-lot variation and support long-term study continuity.
• Well-stocked inventory: Fresh, high-quality microsomes are readily available.
• Customizable options: Gender, species, vial size, and batch size available upon request.

Quality

• Protein concentration: 20 mg/mL
• Metabolic activity: Characterization of phase I (CYP1A, 3A, 2C, 2D, FMO) and phase II (ECOD, UGT) drug-metabolizing enzymes
• Metabolic stability: Determine the half-life of testosterone, verapamil, raloxifene