Mouse Intestine Microsomes

Details

Mouse intestine microsomes, derived from intestine tissue, are essential for studying oral drug first-pass metabolism and intestine enzyme functions. They provide a specialized platform for intestine metabolism research due to their rich CYP3A and UGT enzyme content, making them a key tool for predicting oral drug bioavailability. Isolated via differential centrifugation and validated for enzyme activity by MileCell, these microsomes are available from multiple species including mouse, rat, dog, monkey, minipig, rabbit, feline, hamster, etc.

Product Features

• Quality assurance: All batches undergo comprehensive quality control procedures to ensure product integrity and batch-to-batch consistency.
• Comprehensive characterization: Characterization of key CYP450 and phase II enzyme activities, ensuring exceptional metabolic performance and specificity for consistent and reliable results.
• Scalable production: Large lots derived from donor pools of intestine subcellular fractions to minimize lot-to-lot variation and ensure long-term availability across experimental replicates.
• Available intestine preparations format: PMSF-containing‌ and PMSF-free.
• Well-stocked, fresh & viable Inventory‌.
• Customizable: Gender, species, vial size, batch size, etc.

Quality

• Protein concentration: 10 mg/mL
• Metabolic activity: Characterization of phase I (CYP3A) and phase II (UGT) drug metabolizing enzymes
• Metabolic stability: Determine the half-life of Testosterone, Verapamil, Raloxifene